OptiMSM®: Back to Basics…....What do you know about Sulphur?

Did you know that sulphur is the third most abundant mineral in the human body? While our bodies contain sulphur-containing amino acids (SAAs) such as methionine, cysteine, and others that can donate sulphur to biochemical reactions, these amino acids have essential functions themselves in their intact state. If dietary sulphur intake is low, SAA production in the body is reduced, and stripping sulphur from SAA’s to use elsewhere leaves us at limited functional capacity.

OptiMSM® provides the body an easily accessible pool of sulphur, which spares the essential sulphur-containing amino acids (SAAs) methionine and cysteine from being metabolised for their sulphur. Its role as a sulphur donor, and its ability to preserve SAAs explains the broad range of health benefits with MSM supplementation. A study proved rapid absorption of OptiMSM® and incorporation into tissue proteins.1

Sulphur is well-recognized for its roles in supporting healthy skin, including appearance, acne, and wound healing.2 Working within the skin, sulphur is an integral part of the antioxidant and detoxification processes necessary to protect and maintain proper skin growth.3 Plus MSM has showed many benefits for joint health and in reducing exercise-induced oxidative stress and muscle damage.4-10

LEHVOSS Nutrition offers OptiMSM® which is a branded form of MSM manufactured in the U.S. in a single-purpose production facility and purified through a proprietary multi-stage distillation process. This process removes impurities by utilizing unique boiling points to isolate the MSM molecules. Distillation also guarantees low moisture content, reducing the risk of micro-contamination and degradation.

For more information visit our dedicated OptiMSM® page or contact us.


(1) Wong T, Bloomer R, Benjamin R, Buddington R. Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice. Nutrients. 2017;10(1):19. doi:10.3390/nu10010019

(2) Gupta AK, Nicol K. The use of sulfur in dermatology. J Drugs Dermatol. 2004;3(4):427-431. http://www.ncbi.nlm.nih.gov/pubmed/15303787. Accessed July 3, 20192. Komarnisky LA, Christopherson RJ, Basu TK. Sulfur: its clinical and toxicologic aspects. Nutrition. 2003;19(1):54-61. doi:10.1016/S0899-9007(02)00833-X

(3) Palego L, Betti L, Giannaccini G. Sulfur Metabolism and Sulfur-Containing Amino Acids: I- Molecular Effectors. Biochem Pharmacol. 2015;04(01):1-8. doi:10.4172/2167-0501.1000158

(4) Usha PR, Naidu MUR. Placebo-Controlled Study of Oral Glucosamine , Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Invest. 2004;24(6):353-363.

(5) Kim, LS; Axelrod, LJ; Howard, P; Buratovich N. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthr Cartil. 2006;14:286-294.

(6) Debbi EM, Agar G, Fichman G, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11(1):50. doi:10.1186/1472-6882-11-50

(7) Pagonis TA, Givissis PA, Kritis AC, Christodoulou AC. The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility. Int J Orthop. 2014;1(1):19-24. doi:10.6051/j.issn.2311-5106.2014.01.7

(8) Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial. Acta Med Indones.2017;49(2):105-111. http://www.ncbi.nlm.nih.gov/pubmed/28790224.

(9) Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002;7(1):22-44.

(10) Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. J Phar Pharmacol. 2011;63(10):1290-1294. doi:10.1111/j.2042-7158.2011.01314.