Citrus Bioflavonoids and their multiple benefits

For more than 10 years we have offered to our customers a high quality and consistent supply of citrus bioflavonoids for use in food supplements. The material is a fine powder (80mesh) with minimum 60% Hesperidin by HPLC, from sweet oranges.

Citrus flavonoids, especially those found in lemons like hesperidin, have been extensively researched. What is interesting about citrus flavonoids when managing blood glucose levels is their unique multipronged approach. Similar to other ingredients, citrus flavonoids help to improve insulin sensitivity and balance the inflammatory response,1 and because of their strong antioxidant capacity2,3 citrus flavonoids help to efficaciously manage blood glucose levels.

Hesperidin has also been reported to boost recovery after intense exercise by improving oxidation and inflammation. A recent study (2021) demonstrated that acute and chronic intake of 500mg of 2S-hesperidin in amateur cyclists, significantly improved anaerobic performance.4

Flavonoids may also play a role in protecting cognition, according to a Harvard study, published online in July 2021 by Neurology. Scientists evaluated the self-reported diet and memory information of more than 77,000 middle-aged men and women, who were followed for 20 years. After accounting for factors that could have affected cognition (such as age, weight, physical activity, alcohol intake, depression, and intake of nutrients other than flavonoids), scientists found that people with the highest daily flavonoid intakes were 19% less likely to report trouble with memory and thinking, compared with people who had the lowest daily flavonoid intakes.5

Contact your sales representative to receive an offer. Material is normally in stock* from our UK and EU warehouses, ready for shipment. Visit our citrus bioflavonoids page to learn more.


(1) Assini JM et al. “Citrus flavonoids and lipid metabolism.” Curr Opin Lipidol. 2013;24(1):34-40.

(2) Gattuso G et al. “Flavonoid Composition of Citrus Juices.” Molecules. 2007;12(8):1641-1673.

(3) Ferreira PS et al. “Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat diet.” Food Funct. 2016;7(6):2675-2681.

(4) Martinez-Noguera et al. “8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists” Antioxidants 2021, 10(3), 432

(5) Yeh et al. “Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women” Neurology, July  28, 2021 DOI:

*Please note that stock may vary due to unexpected demand.