Punicalagins: The Hidden Benefits of Pomella® Pomegranate Extract

Pomegranates are recognised as an antioxidant powerhouse, largely due to their polyphenol content. Punicalagins, bioactive polyphenols, are responsible for most of the pomegranate’s clinically observed benefits. Standardised to 30% punicalagins and clinically researched Pomella® offers formulators a consistent, science-led solution, delivering bioactive punicalagins, and their gut-derived metabolites, urolithins, while supporting sustainability.

Pomella® Pomegranate Extract, rich in punicalagins, demonstrates significantly higher antioxidant activity compared to other botanical extracts containing high amounts of polyphenos¹. By focusing on punicalagins and building research around them over the years, Pomella® offers a distinctive positioning to formulators, focusing on innovative health applications such as skin and microbiome.

Recent human studies highlight Pomella®’s role in modulating the gut microbiome² and increasing short-chain fatty acids, alongside benefits for skin health and the gut–skin axis^3,4, including measurable reductions in wrinkle severity, improvements in skin barrier function and increase of beneficial skin microbiome. Additionally, new clinical data in oral care demonstrates that Pomella® may deliver rapid (within 30 minutes of rinsing) and significant antiplaque and antimicrobial benefits, outperforming standard broad-spectrum antiseptic and disinfectant mouthwashes in the short term^5,6.

For formulators, this evolving science translates into clear innovation opportunities. At clinically validated dosages of 250–600 mg/day, Pomella® benefits from clinical studies across cardiovascular, beauty-from-within, gut health, oral care, cognitive, cartilage protection, healthy aging applications and more.

Discover more about the power behind Pomella® Pomegranate extract – download our Product Profile Sheet here or contact us for more details!

_{References
(1) Henning SM et al. Variability in the antioxidant activity of dietary supplements from pomegranate [Pomella], milk thistle, green tea, grape seed, goji, and acai: Effects of in vitro digestion. J Agric Food Chem. 2014 Apr 18. 62: 4313-4321. DOI: 10. 1021/jf500106r3.
(2) Sivamani RK et al. Prospective, randomized, double-blind, placebo-controlled study of a standardized oral pomegranate extract on the gut microbiome and short-chain fatty acids. Foods. 2023 Dec 19. 13(1): 15pgs. doi: 10.3390/foods13010015
(3) Chakkalakal M et al. Prospective randomised double-blind placebo-controlled study of oral pomegranate extract [Pomella®] on skin wrinkles, biophysical features, and the gut-skin axis. J Clin Med. 14 Nov 2022. 11(22): 6724. doi: 10.3390/jcm11226724
(4) Pacheco-Palencia LA et al. Protective effects of standardised pomegranate (Punica granatum L) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. J Agric Food Chem.2008 Jul 18. EPub 2008 Aug 22. DOI: 10. 1021/jf80053076
(5) DiSilvestro RA et al. Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk. Phytother Res. 2009. 23: 1123-1127. EPub 2009 Jan 23. DOI: 10.1002/ptr.27597.
(6) Sasi et al. Efficacy of Pomegranate Mouthrinse Compared to Chlorhexidine on Plaque Accumulation, Gingival Inflammation, and Salivary Bacterial Count: A Randomized Controlled Trial. Cureus - Part of Springer Nature - doi:10.7759/cureus.93612
(7) Goyal R et al. An antioxidative effect of Punica granatum (pomegranate) on biomedial parameters in patients with myocardial infarction: A double blind placebo controlled trial. Eur J Biomed Pharma Sci. 2016 Apr 30. Vol 3 (Issue 5): 662-667
(8) Liu W et al. Development of a neuroprotective potential algorithm for medicinal plants. University of Rhode Island. Neurochem Int. 29 Sep 2016. 100: 164-1778.
(9) Liu W et al. Pomegranate phenolics inhibit formation of advanced glycation end products by scavenging reactive carbonyl species. Food and Function. 2014. 5: 2996-30042.}