Witholytin®: Brain Energy through Mitochondrial Health

Healthy mitochondrial function is essential for mental clarity, sustained energy release and everyday cognitive performance. Recent research demonstrates that Witholytin® Ashwagandha may help support brain health by influencing mitochondrial biogenesis and neuroenergetics in cortical neurons. The clinical study¹ shows that Witholytin® phytoactives interact with Brain Derived Neurotrophic Factor (BDNF) and Sirtuin 1 (SIRT1) signalling pathways, which are involved in neuronal growth, stress adaptation, metabolic regulation and healthy brain ageing.

These mechanisms may help enhance the production, distribution and utilisation of energy within the brain, supporting cognitive performance and resilience. The findings also indicate that Witholytin® Ashwagandha may promote the formation of new mitochondria.

This helps neurons meet the high energy demands associated with focus, concentration and everyday mental performance. Plus, its neuroprotective properties may help support healthy brain function over time.

In addition to the recently studied effects on mitochondrial health, Witholytin® has also demonstrated benefits for stress, fatigue and overall wellbeing. In a clinical study² involving adults experiencing low energy and moderate-to-high stress levels, supplementation with Witholytin® resulted in a 45.81% reduction in fatigue and a 38.59% decrease in perceived stress, highlighting its potential as a natural solution for supporting both mental and physical resilience.

From Verdure Sciences®, the makers of Longvida® Curcumin Extract and Bacognize® Bacopa Extract, Witholytin® is the only ashwagandha extract that is USP Verified and Alkemist Assured™, ensuring ingredient quality through rigorous testing for identity, potency and contaminants. Standardised to 1.5% total withanolides from the root and backed by scientific research and stringent quality standards, Witholytin® offers a trusted and sustainable solution for formulations targeting energy, mental wellbeing and stress management.

For more information, download our Witholytin® Product Profile Sheet here or contact us.

_{References
(1) Fanibunda et al. (2025) Withania somnifera Regulates Mitochondrial Biogenesis and Energetics in Rat Cortical Neurons: Role of BDNF and SIRT1.org/10.1007/s12035-025-04920-7.
(2) Smith SJ et al. (Sept 2023). Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®).J Psychopharmacol. doi: 10.1177/02698811231200023.}