Science Meets Mobility: How AmLexin® Preserves Cartilage Integrity

Written by

Cartilage integrity is fundamental to long-term joint function. While many joint health ingredients focus mainly on comfort and flexibility, AmLexin® takes a proactive approach by helping preserve cartilage integrity, while supporting one of the key structures responsible for healthy joint function.

AmLexin® is a clean-label, plant-based formulation backed by extensive preclinical and clinical research. In a 12-week study involving 135 adults across different age groups with knee discomfort, participants taking 400 mg/day of AmLexin® showed a reduction in uCTX-II, a biomarker of type II collagen degradation and cartilage breakdown1.

AmLexin® has also demonstrated its ability to help protect cartilage from degradation.

In ex vivo studies, AmLexin® reduced glycosaminoglycan (GAG) release, inhibited proteoglycan degradation and demonstrated significant improvements in cartilage matrix integrity².

Recent research shows that AmLexin™ works synergistically with Univestin® to provide complementary joint support. Univestin® is associated with rapid improvements in stiffness, while AmLexin® provides clinically demonstrated cartilage support. Together both ingredients may address immediate joint comfort and long-term joint integrity3.

AmLexin® was developed using Unigen's proprietary Phytologix® Technology Platform, which contains comprehensive botanical profiles on more than 12,000 plants and data from thousands of extracts and fractions. This science-driven approach enabled the identification of plant-derived actives with targeted health benefits, leading to the discovery of the unique botanical combination behind AmLexin®.

Supported by a growing body of preclinical and clinical research, AmLexin® helps maintain cartilage quality alongside healthy joint function. Combined with its strong safety profile, this makes AmLexin® an appealing ingredient for innovative mobility products.

For more information, download our AmLexin® product profile sheet here or contact us.

References
(1) Kalman DS, Hewlings SJ. The Effects of Morus albaand Acacia catechuon Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee. J Nutr Metab. 2017;2017:4893104. doi: 10.1155/2017/4893104. Epub 2017 Sep 11. PMID: 29085676; PMCID: PMC5612321.
(2) Yimam M, Lee YC, Wright L, Jiao P, Horm T, Hong M, Brownell L, Jia Q. A Botanical Composition Mitigates Cartilage Degradations and Pain Sensitivity in Osteoarthritis Disease Model. J Med Food. 2017 Jun;20(6):568-576.
(3) Yimam M et al. (2017) Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu, Evid Based Complement Alternat Med. 2017 Aug 20;2017:7059068. doi: 10.1155/2017/7059068.
Back to the News Section