Microbiome & Beauty: How Pomella® Supports Skin Health

The gut-skin axis is an emerging area of microbiome research, highlighting the connection between gut health, skin composition, appearance and overall skin wellbeing. Innovative research on Pomella® Pomegranate Extract demonstrates how targeted microbiome modulation may help support skin barrier function and improve the appearance of ageing skin.¹

In a randomised, double-blind, placebo-controlled human study, 250mg/day Pomella® significantly reduced wrinkle severity while supporting favourable microbiome changes. Improvements in skin barrier function further demonstrated the ingredient's potential to support skin health through the gut-skin axis.¹ Standardised to 30% punicalagins, highly bioavailable pomegranate polyphenols, Pomella® is a clinically researched ingredient that provides key bioactive compounds and their gut-derived metabolites, urolithins.

By combining microbiome modulation with skin health support, it offers formulators a compelling opportunity for beauty-from-within innovation.

Researchers found that Pomella® supplementation increased beneficial members of the facial skin microbiome, including the Bacillus genus and Staphylococcus epidermidis. Higher levels of Eggerthellaceae in the gut microbiome were also associated with reductions in both transepidermal water loss (TEWL) and wrinkle severity.¹

In addition to its clinically demonstrated benefits, Pomella® has been shown to protect human skin fibroblasts from UV-induced damage while supporting intracellular antioxidant capacity and reducing oxidative stress.² These findings further reinforce Pomella®'s value as an innovative ingredient, combining clinically demonstrated skin benefits with antioxidant support.

Beyond its scientific credentials, Pomella® is backed by a commitment to responsible sourcing initiatives. According to Verdure Sciences®' Sustainability Report, Pomella® Pomegranate Extract Programme incorporates farmer training, drip-irrigation practices, biofertilizer use, and processing initiatives. The report further describes agricultural and community programmes implemented across the supply chain.

For more information, download our Pomella® Product Profile Sheet here or contact us.

_{References
(1) Chakkalakal M et al. Prospective randomised double-blind placebo-controlled study of oral pomegranate extract [Pomella®] on skin wrinkles, biophysical features, and the gut-skin axis. ( 2022) doi:10.3390/jcm11226724.
(2) Pacheco-Palencia et al. Protective effects of standardised pomegranate (Punica granatum L) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. (2008) doi:10.1021/jf80053076.}