New Study: Witholytin® and Mitochondrial Health

Exciting new research has been published (April 2025) demonstrating how Witholytin®, our branded, natural ashwagandha, significantly influences mitochondria in cortical neurons whilst also potentially bolstering stress adaptation and neuroprotection.

Data suggests these effects are driven by interactions with Brain Derived Neurotrophic Factor (BDNF) which are essential for neuron support and growth, and Sirtuin 1 (SIRT1) signalling which is crucial for neuronal development and metabolic balance during aging.

These initial findings propose that Witholytin® could enhance the creation of new mitochondria (mitochondrial biogenesis) and also improve neuroenergetics – the production, distribution and utilisation of energy within the brain – in cortical circuits.

This discovery is particularly compelling as it points to how Witholytin® helps brain cells manage stress and protect themselves from damage¹.

Moreover, Witholytin®’s neuroprotective qualities and influence on energy pathways in the brain suggest potential applications in supporting individuals with, or at risk of, neurodegenerative disorders. Additionally, it could also offer an adaptogenic solution, backed by research demonstrating its effectiveness against fatigue and stress.

Witholytin® is a sustainably sourced ashwagandha extract, distinguished by its unique, standardised withanolides profile. This premium, branded ingredient is the only Alkemist Assured™ and USP Verified Ashwagandha. For more information, visit our Witholytin® dedicated page or contact us.

_{References
(1) Fanibunda et al. (2025) Withania somnifera Regulates Mitochondrial Biogenesis and Energetics in Rat Cortical Neurons: Role of BDNF and SIRT1. doi.org/10.1007/s12035-025-04920-7}